COVID-19 Vaccine Sole Intend Like In use Applications Can not Express Consequences?
January 13, 2021 Health
Even after almost a year of its worldwide invasion the SARS-Cov-2 virus called COVID-19 continues to savor an edge over humankind that will be not surprising considering the unprecedented crisis earned by a disease hardly proven to anybody, its seemingly selective approach in terms of mildness or severity of the infection, baffling all medical scientists and doctors. Humankind, in its present very advanced stage of the information search, is never a party to simply accept defeat, and therefore, the quest has been relentlessly going on all over for a successful vaccine, and for the time being intent research on anti-viral or anti-malarial repurposed drugs, plasma therapy and other possible types of treatment. The principal interest of efforts being at least to lessen the mortality rates which also differ country-wise and inexplicably, and till today it has been an accepted fact that there surely is no cure for the disease. Various vaccine projects in a variety of stages of development are in full swing in a variety of countries with many of them promising a vaccine by the newest year day or early next year. Now, the latest disappointing developments on treatment methods practiced to date have posed probably the most relevant question: is a successful vaccine only a cure for humankind?
Most of us remember the desperate international craving for a basically Indian anti-malarial drug called Hydroxychloroquine (HCQ) once the pandemic was raging furiously in Europe and the US, and the US President going to the extent of threatening India if supplies of HCQ were not. However, slowly over time this drug was found ineffective and a little harmful too in respect to natural immunity โควิด 19. Then there were several other drugs and steroids that were used in combination with seemingly hopeful results, Remdesivir being the one most welcomed one as a life-saver.
The results of the Solidarity Clinical Trial, among the largest international Randomized Controlled Trials (RCT), that has been conducted by the World Health Organization (WHO) since March 2020 were declared recently which marked four of the most promising drugs as ineffective in reducing mortality. The four evaluated treatment methods, HCQ, Remdesivir, Lopinavir or Ritonavir and Interferon, have been found to have little if any effect on mortality rates. In terms of the RCTs conducted in a variety of countries of the world including in China are involved there will always be doubts on their findings, and experts want for more such studies. Objections were raised contrary to the Solidarity Trial too as regards to its sampling methodology from various quarters, with one Indian hospital refusing to stop using Remdesivir claiming its benefits within the months inside their patients. However, technically, it means that with the exception of Corticosteroids that have been proven effective in treating critical patients there is no other deemed treatment method, and in addition it should be remembered that steroids are not recommended for less-severe or general patients.
More disappointing news came next from the Indian Council of Medical Research (ICMR) on the efficacy of the Convalescent Plasma Therapy (CPT), to date permitted being an investigational therapy in progressive stages of the condition in India, which involves taking out blood plasma from recovered COVID-19 patients and injecting this antibody-rich extract into positive patients, specially the more severe ones treated in hospitals. On the months it has been developed into an organized treatment method creating proper channels of donations over the states as infected doctors too made it a point to donate the precious plasma.
The Director General of the ICMR declared the results on 20th October 2020 after conducting a unique RCT during April-July amount of the season covering over 400 hospitals across 39 medical centers of the country. On the basis of the results the ICMR has figured the CPT fails to lessen the mortality rates or avoid the progression of COVID-19 infections from moderate to severe stages. Following this finding the Government of India is mulling removal of CPT from its COVID-19 protocol for national clinical management. This is indeed sad news as CPT is a extremely popular way of COVID-19 treatment in the absence of a successful vaccine.
Experts, however, are not convinced concerning the CPT results saying that it may have had regarding the delay of the infusion and the quality of the antibodies. Internationally, the CPT remains a treatment method meant limited to emergency use. Anyway, because of these findings the significance of discovering a successful vaccine grows even more. The pandemic is not even close to keeping its clutches off humankind yet: after over six months of haphazard acceleration India has finally reached its peak in the next week of September 2020 with new cases still hovering around fifty thousand each day and 500+ daily deaths whilst the European countries and the US are experiencing an additional wave.
Chinmay Chakravarty is just a professional specialized in the creative field with over 2 full decades of experience in journalistic writing, media co-ordination, film script writing, film dubbing, film & video making, management of international film festivals and editing of books & journals. Experienced in providing professional services in these related fields. Was an officer of Indian Information Service and superannuated from the post of Director, Press Information Bureau, Kolkata in November, 2019. Published his first solo book’Laugh and Let Laugh’in 2017.